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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, WI, United States



Survival: 17.8 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Madison, WI
   
Hospital: University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
   
Journal: Link
   
Date: 4/2008

Description:
Patients: This phase II study involved 70 men with androgen-independent prostate cancer. They ranged in age from 52 to 85 years.

Treatment: Patients were treated with the chemotherapy drug docetaxel alone or in combination with doxercalciferol. Doxercalciferol is a ‘prohormone’ similar to Vitamin D, a nutrient found in foods.

Toxicities: Grade 3 and 4 toxicities included abdominal cramping, diarrhea, dyspnea, edema, hyperglycemia, infection, nail change nausea, febrile neutropenia, pleural effusion, thrombocytopenia, thrombosis/embolism. Each of these were reported in 10 or fewer patients.

Results: The median overall survival was 17.8 months for patients treated with docetaxel and doxercalciferol, and 16.4 months for patients treated with docetaxel alone

Support: This study was supported in part by research funds from Genzyme and Sanofi-Aventis. Sanofi-Aventis markets docetaxel as Taxotere.

Correspondence: Dr. Glenn Liu

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