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Lung Cancer treatment details. Alternative. Chemotherapy. National Cancer Center Hospital, Chuo-ku, Tokyo, Japan



Survival: 16.0 months
   
Toxicity Grade: 5
   
Treatments: Alternative
Chemotherapy
   
Drugs: Pemetrexed
Country: Japan
   
City/State/Province: Chuo-ku, Tokyo
   
Hospital: National Cancer Center Hospital
   
Journal: Link
   
Date: 7/2008

Description:
Patients: This phase II study involved 226 patients with advanced non-small cell lung cancer. They ranged in age from 26 to 74 years of age.

Treatment: Patients were treated with the chemotherapy drug pemetrexed and given nutritional supplements of folic acid and vitamin B12. Patients were given two different doses of pemetrexed.

Toxicities: One patient died from pneumonitis/interstitial lung disease. Grade 4 neutropenia, lymphopenia, and anemia were reported (each in less than 5% of patients). These toxicities at a grade 3 severity were also reported, as were leukopenia, anorexia, diarrhea, constipation, rash, and pneumonitis.

Results: The median overall survival was 16 months for patient treated with the lower dose of pemetrexed (500mg/m2) and 12.6 months for those treated with the higher dose (1000mg/m2)

Support: This study was supported by research funds from Eli Lilly, which markets pemetrexed as Alimta“

Correspondence: Dr. Yuichiro Ohe

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