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Brain Cancer treatment details. Chemotherapy. Radiation. Istituto Nazionale Neurologico Carlo Besta, Milan, Italy



Survival: 18.6 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
   
Drugs: BCNU, BiCNU
Platinol
Country: Italy
   
City/State/Province: Milan
   
Hospital: Istituto Nazionale Neurologico Carlo Besta
   
Journal: Link
   
Date: 12/2002

Description:
Patients: This study involved 30 newly diagnosed patients with glioblastoma. The patients were divided into two groups (A and B) of 15 patients each.

Treatment: Patients in Group A received intraarterial chemotherapy consisting of carboplatin (paraplatin) plus ACNU. Patients in Group B received intravenous chemotherapy consisting of cisplatin (platinol) plus BCNU. After the second course of chemotherapy and before the third cycle, all patients received radiotherapy.

Toxicity: For group B, grade 3 and 4 leukopenia occurred in 9 patients and 4 patients respectively. Grade 3 and 4 thrombocytopenia occurred in 7 and 2 patients respectively. One patient experienced focal seizures several hours after the end of treatment. One patient developed grade 3 anemia.

Results: Median survival time was 18.6 months (group B).

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