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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Mayo Clinic, Rochester, MN, United States

Survival: 15.3 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Rochester, MN
Hospital: Mayo Clinic
Journal: Link
Date: 10/2008

Patients: This phase 1/2 study involved 97 patients with recently diagnosed glioblastoma. The median age was 57, ranging from 31 to 84 years old. About half (42) of the patients were women.

Treatment: Patients were treated with the biological therapy erlotinib, and radiation therapy with temozolomide.

Toxicity: Two patients died, after they developed pneumonia. The most common toxicities were rash, fatigue, thrombocytopenia, diarrhea, leucopenia, and neutropenia. Grade 4 toxicities were rash, fatigue, thrombocytopenia, leucopenia, and neutropenia and each occurred in less than 10% of patients.

Results: The median overall survival was 15.3 months.

Support: One of the authors of the study has received research funds from Genentech, which markets erlotinib as Tarceva.

Correspondence: Dr. Paul Brown

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