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Brain Cancer treatment details. Biologic therapy. Erasmus University Hospital, Rotterdam, Netherlands



Survival: 5.9 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Netherlands
   
City/State/Province: Rotterdam
   
Hospital: Erasmus University Hospital
   
Journal: Link
   
Date: 10/2008

Description:
Patients: This phase 2 study involved 112 patients with recurrent gliomas. Fifty-one patients had glioblastoma, 25 had anaplastic astrocytomas, and 36 had anaplastic oligodendroglioma/mixed oligoastrocytoma. They ranged in age from 19 to 72 years.

Treatment: Patients were treated with one of two doses of the biological therapy imatinib.

Toxicity: In patients treated with the higher dose of imatinib, 5 experienced grade 3 or 4 febrile neutropenia. Other grade 3 or 4 toxicities included neutropenia without fever, anemia, fatigue, vomiting, and edema. Toxicities of grade 3 and 4 severity were reported in 11% or less of patients. Grade 1 to 2 edema was reported in almost half of patients, regardless of treatment group.

Results: The median overall survival (irrespective of drug dose) was 5.9 months for patients with glioblastoma, 5.3 for those with anaplastic oligodendroglioma/mixed oligoastrocytoma; and 5.0 months for those with anaplastic astocytoma. Patients treated with the higher dose of drug did not have a longer survival time.

Support: This study was supported by research funds from Novartis, which developed and markets imatinib as Gleevec.

Correspondence: Dr. Martin J. van den Bent

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