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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. Duke Comprehensive Cancer Center, Durham, NC, United States



Survival: 17.6 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Durham, NC
   
Hospital: Duke Comprehensive Cancer Center
   
Journal: Link
   
Date: 10/2008

Description:
Patients: This phase I-II study involved 31 patients with metastatic, castration-resistant prostate cancer. The median age was 68, ranging from 50 to 81 years of age. Most (81%) had bone metastases.

Treatment: These patients were treated with the chemotherapy drug docetaxel and the biological therapy atrasentan.

Toxicity: Grade 3 and 4 toxicities included neutropenia, pain, and peripheral edema. Grade 4 febrile neutropenia was reported in the patients receiving the highest dose of treatment.

Results: The median overall survival was 17.6 months.

Support: This study was supported in part by research funds from Abbott Laboratories, which developed atrasentan.

Correspondence: Dr. Andrew J. Armstrong

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