Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Breast Cancer treatment details. Biologic therapy. City of Hope Comprehensive Cancer Center, Duarte, CA, United States



Survival: 24.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Duarte, CA
   
Hospital: City of Hope Comprehensive Cancer Center
   
Journal: Link
   
Date: 11/2008

Description:
Patients: This phase 2 study involved 14 women with metastatic breast cancer. The median age was 60.5, ranging from 37 to 89 years of age. Most (12) had previously received chemotherapy for their breast cancer.

Treatment: These women were treated with vorinostat (suberoylanilide hydroxamic acid). Vorinostat is a small molecule that inhibits the action of certain proteins called HDAC enzymes.

Toxicity: Two grade 4 toxicities occurred, mucositis and lymphopenia. Grade 3 fatigue, nausea/vomiting, dehydration, hypokalemia, and thrombocytopenia were each reported in one patient.

Results: The median overall survival was 24 months.

Correspondence: Dr. George Somlo

E-mail to a Friend Email Physician More Information