Cancer Treatment Results  Survival Rates Cancer Treatments / Therapy Results
Cancer
 

Click here to go back to your search results.

Brain Cancer treatment details. Biologic therapy. Gene Therapy. Surgery. University of California, San Francisco, San Francisco, Californai, United States



Survival: 8.4 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Gene Therapy
Surgery
   
Drugs:
Country: United States
   
City/State/Province: San Francisco, Californai
   
Hospital: University of California, San Francisco
   
Journal: Link
   
Date: 12/2003

Description:
Patients: This Phase I/II multi-institutional trial involved 30 patients with progressive or recurrent glioblastoma multiforme.

Treatment: Treatment consisted of surgical resection of tumor followed by injections of vector producing cells (VPC) (a type of gene therapy) into the brain adjacent to the cavity. An Ommaya reservoir placed after surgery was used to inject a further dose of VPC after surgery, followed by ganciclovir. Further gene therapy was given at 28-day intervals.

Toxicity: Two patients died of deep vein thrombosis and pulmonary embolism. The most frequent toxicities were neurological. Approximately 90% of patients experienced at least one serious adverse event. Serious adverse events while on treatment included: seizures, acute meningeal/ventricular reaction, hemiplegia/hemiparesis, speech problem, subdural hematoma, cerebral edema, intracerebral hemorrhage, lymphopenia, pancytopenia, hyponatremia, fever, pneumonia, septicemia (from catheter), perforated ulcer, ileus, and Ommaya reservoir complications.

Results: Median survival was 8.4 months.

Support: Supported by a grant from Genetic Therapy, Inc. and MD/Novarts Pharmaceuticals. These companies are involved in the production of VPC.

Correspondence: Michael Prados, MD

E-mail to a Friend Email Physician More Information