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Brain Cancer treatment details. Biologic therapy. Duke University Medical Center, Durham, North Carolina, United States



Survival: 9.2 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Durham, North Carolina
   
Hospital: Duke University Medical Center
   
Journal: Link
   
Date: 1/2004

Description:
Patients: This Phase II trial involved 57 patients with first recurrence of a glioblastoma who were previously treated with surgical resection, radiation, and usually chemotherapy underwent an open biopsy or resection at evaluation for confirmation of tumor recurrence.

Treatment: Treatment consisted of gefitinib. Gefitinib is a novel epidermal growth factor receptor tyrosine kinase inhibitor.

Toxicity: Grade 4 toxicities related to treatment included rash and diarrhea. (Grade 4 seizure and intracerebral hemorrhage were “deemed either unrelated or unlikely to be related to gefitinib use.”) Other toxicities included: conjunctivitis (grade 2-3), onycholysis (grade2-3), ALT elevation (grade 1-3), anorexia (grade1), weight loss (grade 1), and deep vein thrombosis (grade 3).

Results: Median overall survival was 9.2 months.

Correspondence: Jeremy N. Rich, MD

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