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Ovarian Cancer treatment details. Chemotherapy. Memorial Sloan-Kettering Center, New York, NY, United States

Survival: 15.4 months
Toxicity Grade: 4
Treatments: Chemotherapy
Country: United States
City/State/Province: New York, NY
Hospital: Memorial Sloan-Kettering Center
Journal: Link
Date: 12/2008

Patients: This phase 2 study involved 78 women with ovarian cancer. They ranged in age from 30 to 89 years old. Most (85%) had received two previous chemotherapy treatments.

Treatment: Patients were treated with paclitaxel poliglumex, a chemotherapy drug attached to a little molecule thought to make more of the drug be picked up by the tumor cells. The patients were divided into two groups, or cohorts, and received one of two different amounts of the drug.

Toxicity: Grade 4 neutropenia was reported in both cohorts (in about 10% of patients), and in the higher-dose group, there was one report of grade 4 neuropathy and pain. Grade 3 toxicities included neutropenia, anemia, allergy, gastrointestinal, infection, neuropath, and pain. The most common grade 3 toxicities were neutropenia and neuropathy, occurring in about a third of patients.

Results: The median overall survival was 15.4 months.

Correspondence: Dr. Paul Sabbatini

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