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Breast Cancer treatment details. Biologic therapy. Vanderbilt University Medical Center, Nashville, TN, United States



Survival: 27.0 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Nashville, TN
   
Hospital: Vanderbilt University Medical Center
   
Journal: Link
   
Date: 10/2008

Description:
Patients: This study involved 35 women with metastatic breast cancer. They median age was 56, ranging from 30 to 83 years. Most (63%) were post-menopausal.

Treatment: Patients were treated with trastuzumab and gefitinib. These are both biological therapies. Trastuzumab is a monoclonal antibody and gefitinib is a small molecule.

Toxicity: Grade 3 or 4 diarrhea, rash, nausea/vomiting, pruritis, conjunctivitis, and abnormal laboratory finding were reported. The most common was diarrhea, experienced by 32% of patients. One patient had grade 4 neutropenia.

Results: The median overall survival was 27 months.

Correspondence: Dr. Carlos L. Arteaga

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