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Liver Cancer treatment details. Biologic therapy. The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States



Survival: 19.2 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: The University of Texas M.D. Anderson Cancer Center
   
Journal: Link
   
Date: 12/2008

Description:
Patients: This study involved twenty-eight patients with advanced hepatocellular carcinoma. Eighteen of the patients were men. These patients ranged in age from 30 to 85 years old, and the average age was 62.8 years

Treatment: Patients were treated with TAC-101, which is a biological therapy that is chemically similar to vitamin A.

Toxicity: Five patients experienced one or more grade 3 and 4 toxicities; increased serum AST (liver enzyme) levels, dermatitis, fatigue, pancreatitis, pruritis, deep vein thrombosis and pulmonary embolism. Other toxicities including rigors, constipation, leucopenia, arthritis, muscle pain, and headache were reported.

Results: The median overall survival was 19.2 months.

Correspondence: Dr. Melanie B. Thomas

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