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Breast Cancer treatment details. Biologic therapy. Albert Einstein College of Medicine, Bronx, NY, United States

Survival: 19.4 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Bronx, NY
Hospital: Albert Einstein College of Medicine
Journal: Link
Date: 4/2009

Patients: This phase 2 study involved 33 women with metastatic or surgically incurable advanced breast cancer. They were all post-menopausal. The median age was 61 years, ranging from 39 to 77.

Treatment: Patients were treated with tipifarnib and fulvestrant. Tipifarnib is a small molecule that inhibits other molecules in cancer cells from being active. Fulvestrant is a drug that targets the estrogen receptor.

Toxicity: Five grade 4 toxicities were reported; two reports of neutropenia and one each of thrombosis, myocarditis, and pericardial effusion. Other toxicities (grade 1-3) included anemia, infection, nausea/vomiting, anorexia, fatigue, insomnia, neuropathy, and dyspnea.

Results: The median overall survival was 19.4 months.

Correspondence: Dr. T. Li

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