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Breast Cancer treatment details. Chemotherapy. CHU Dupuytren, Limoges, France

Survival: 29.2 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: France
City/State/Province: Limoges
Hospital: CHU Dupuytren
Journal: Link
Date: 7/2009

Patients: This phase 2 study involved 54 women with HER-2 negative metastatic breast cancer. Their median age was 58.5, ranging from 31 to 84 years old.

Treatment: These women were treated with the chemotherapy drugs vinorelbine and capecitabine.

Toxicity: One 65 year old woman, who experienced grade 4 neutropenia and grade 3 diarrhea, died from sepsis. Grade 4 toxicities included anemia, leucopenia, neutropenia, and thrombocytopenia. Of these, anemia was the least common (1.9% of patients), and thrombocytopenia the most common (reported in 22.6% of patients). Grade 4 stomatitis, infection, and embolism were reported (each in less than 2% of patients).

Results: The median overall survival was 29.2 months.

Correspondence: Dr. Nicole Tubiana-Mathieu

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