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Brain Cancer treatment details. Chemotherapy. Institut Gustave Roussy, Villejuif, France

Survival: 5.8 months
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Camptosar
Country: France
City/State/Province: Villejuif
Hospital: Institut Gustave Roussy
Journal: Link
Date: 4/2003

Patients: This multicentre Phase II study involved 52 patients with glioblastoma multiforme who had not been administered chemotherapy previously. Patients were divided into two groups 25 patients in group A and 27 patients in group B. Group A consisted of patients with the following characteristics: 1) newly diagnosed glioblastoma; 2) tumor inoperable or incompletely resected; 3) no radiotherapy administered. Group B consisted of patients whose tumor was relapsing after they had already received radiotherapy.

Treatment: Treatment consisted of the chemotherapy drug, irinotecan (camptosar). (In addition, patients in group A would also receive radiotherapy if appropriate.)

Toxicity: Toxicities included grade 3-4 cholinergic syndrome with acute diarrhea, abdominal pain, nausea, vomiting, hypersalivation, sweating and asthenia. Grade 3-4 neutropenia was reported in a total of ten patients (3 in group A and 7 in group B). One patient (in group A) had grade 3 anemia.

Results: The median overall survival was 5.8 months in group A.

Support: Aventis Pharma supplied the irinotecan.

Correspondence: Dr. Eric Raymond

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