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Kidney Cancer treatment details. Biologic therapy. Unité Immunothérapie, Institut Gustave Roussy, Villejuif Cedex, France



Survival: 19.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: France
   
City/State/Province: Villejuif Cedex
   
Hospital: Unité Immunothérapie, Institut Gustave Roussy
   
Journal: Link
   
Date: 9/2009

Description:
Patients: This phase 2 study involved 107 patients with metastatic renal cell carcinoma (kidney cancer). Their median age was 59, ranging from 29 to 80 years of age. These patients had previously received cytokine-based therapy.

Treatment: Patients were treated with sunitinib, either in the morning or at night, before sleep. Sunitinib is a biological therapy that affects a molecule called VEGF.

Toxicity: One grade 5 toxicity, acute myeloblastic leukemia, was reported. Six treatment-related grade 4 toxicites were reported: hematemesis, renal failure, vertigo, dehydration, hyponatremia, and hemorrhagic gastritis.

Results: The median overall survival was 19.8 months.

Support: This study was supported by Pfizer, which markets SUTENT®.

Correspondence: Dr. Bernard Escudier

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