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Brain Cancer treatment details. Biologic therapy. Hygeia Hospital, Athens, Greece

Survival: 6.2 months
Toxicity Grade: 3
Treatments: Biologic therapy
Country: Greece
City/State/Province: Athens
Hospital: Hygeia Hospital
Journal: Link
Date: 10/2009

Patients: This phase 2 study involved 20 patients with glioblastoma multiforme. Three of these patients had a mix of glioblastoma and astrocytoma. There were 14 men and six women in this study.

Treatment: Patients were treated with the biological therapy imatinib.

Toxicity: Grade 3 respiratory toxicity was reported in two patients, urinary tract infection in one, and fatigue/anemia in two patients. Grade 3 central nervous system toxicities were seizure, dysarthria, and epidural hematoma (one of each). One diabetic patient also had poorly controlled blood sugar.

Results: The median overall survival was 6.2 months.

Support: This study was supported by Novartis Pharmaceuticals, which markets imatinib as Gleevec.

Correspondence: Dr. Evangelia Razis

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