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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Cleveland Clinic, Cleveland, OH, United States



Survival: 8.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Cleveland, OH
   
Hospital: Cleveland Clinic
   
Journal: Link
   
Date: 12/2009

Description:
Patients: This phase 2 study involved 27 patients with newly diagnosed glioblastoma multiforme. Their median age was 52 years old. Most (16) had received surgery for their brain tumor.

Treatment: Patients were treated with biological drug erlotinib, the chemotherapy temozolomide, and radiation therapy.

Toxicity: One patient died of sepsis (blood infection) without neutropenia. One died of pneumonia. Two patients died from refractory bone marrow aplasia, which means their bone marrow stopped working to produce immune system cells. Grade 3 or 4 toxicities included thrombocytopenia, anemia, lymphopenia, fatigue, and febrile neutropenia.

Results: The median overall survival was 8.6 months.

Correspondence: Dr. David M. Peereboom

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