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CancerWire
Alternative and Integrative Cancer News & Information
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October 2006
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Greetings!
In this edition of CancerWire we offer the latest
alternative and integrative cancer news, discuss Dr.
Merrill Garnett's provocative book "First Pulse,"
and present information about medicinal mushrooms.
We would also like to welcome our new sponsor - SmartChoiceDrugStore
(SCD) SmartChoiceDrugStore is selling cancer
medications at cost. SCD’s long-term program covers
most cancer medications including many injectables
commonly purchased through your doctor. SCD ships
nationwide with typical savings of 10-75%.
SmartChoiceDrugStore is a fully licensed, United
States pharmacy.
Medications are only purchased directly from the
manufacturer or the nation’s top wholesale company.
Safety is SCD’s #1 priority. Call 1-866-289-6337
for more information.
http://www.smartchoicedrugstore.com/
Remember to take a look at the products and
services for patients and clinicians at the bottom
of the newsletter. These companies are committed to
helping people facing chronic diseases and you
should be familiar with what they have to offer.
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Book Review - "First Pulse" by Dr. Merrill Garnett
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First Pulse: A Personal Journey in Cancer
Research by Dr. Merrill Garnett is a fascinating
personal account of the author’s 40 year quest for
an effective cancer therapy. What makes his story
unique is the paradigm that the author has applied
as he addresses the cancer problem. Unlike most
cancer researchers who think in terms of cellular
and genetic processes, Dr. Garnett thinks in terms
of cellular and genetic energetics or what he calls
“electrogenetics,” which is “the energetic process
which edits the genome during the life of the
organism.” In essence, it’s a question of energy
and electrical potential that Garnett sees at the
core of cancer.
Based on this paradigm, Garnett has been searching
for an agent that exploits the therapeutic
vulnerability of cancer due to the altered energy
metabolism of malignant cells. As detailed in the
book, Dr. Garnett has created and tested nearly
20,000 different organo-metallic compounds
culminating in a palladium/lipoic acid complex. The
palladium/lipoic acid complex is now being tested by
researchers and clinicians.
Below are some quotes from this fascinating book:
Poisoning the gene material didn’t seem to have a
theoretical base. It seemed to be a floundering,
random position that institutions took because they
had nothing else.
I began thinking of biological organic complexes
that might be involved in energy transfer. I
considered that there were metal organic compounds
in which the metal would no longer be raw, binding,
or toxic, but exist as it does in the metal enzymes
of the body.
The tradition has been that, faced with a metabolic
difference between healthy and malignant cells, we
must inhibit the cell’s anaerobic state. My point,
however, is not to poison the ancient anaerobic
glycolysis but to restore the aerobic portion of the
cell metabolism that is missing.
I spent years with cobalt and thirteen years with
vanadium, and studied reactions of molybdenum, tin,
copper, and zinc. Even niobium and platinum.
Eventually I got to palladium around 1990.
DNA over time sets up one of the critical resonant
frequencies of a cellular pulse. Then, over time,
there is the emergence of a tissue pulse, and organ
pulse, and neurologic pulses.
It’s the pulse of energy produced by the
mitochondria rather than the flow of sugars, not the
conversion of small molecules, but rather their
harmonics. So once they’ve come on stream in the
cell they all flow electrically.
We are an open window to nature. We typically see
the organism as a defined entity. But we are
fashioned of the universe, and the universe streams
through us.
Click
here for more information about the book.
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Mushrooms and Immunity
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Mushrooms have become increasingly important as
immune modulating agents and dietary supplements. In
fact, over the last ten years there have been
several thousand journal articles written about
medicinal mushrooms and several hundred specifically
about mushrooms and cancer. Now, an entire medical
journal is dedicated to their study – the
International
Journal of Medicinal Mushrooms
Mushrooms have long been valued as delicious and
nutritional foods by many societies. In Asia, it has
been recognized that certain edible and non-edible
mushrooms can have profound health benefits. In
fact, a limited number of highly purified compounds
derived from certain medicinal mushrooms are now
being used in Asia and the U.S.
To explore this resurgent interest in mushrooms, in
May 2002, Cancer Research UK commissioned a
comprehensive study entitled Medicinal mushrooms:
their therapeutic properties and current medical
usage with special emphasis on cancer treatments.
The authors included: John E. Smith, BSc MSc PhD DSc
FIBiol FRSE, Emeritus Professor of Applied
Microbiology, University of Strathclyde, Chief
Scientific Officer, MycoBiotech Ltd, Singapore; Neil
J. Rowan, BSc MSc PhD MIBiol MIFST, Lecturer,
Department of Bioscience, University of Strathclyde;
and Richard Sullivan, BSc MD PhD, Head of Clinical
Programmes, Cancer Research UK. Much of the
information below comes from the Executive Summary
of this report. The
entire report is available here.
The practice of using fungi, especially mushrooms,
in Chinese Traditional Medicine (TCM), dates back
into antiquity and has been recorded in ancient
Chinese manuscripts. Increased scientific and
medical research in recent decades, especially in
Japan, Korea and China and more recently U.S., is
confirming efficacy and identifying the bioactive
molecules (especially the polysaccharides) which
contain demonstrable anti-cancer activities. Most
appear to act as immune system enhancers though some
can have direct cytotoxic effects on cancer cells.
Only a small number of studies have progressed
successfully to objective clinical assessment in trials.
The main medicinal mushrooms both edible and
non-edible include: Ganoderma lucidum (Reishi or
Ling Zhi), Lentinus (Lentinula) edodes (Shiitake),
Phellinus linteus, Porio cocos, Auricularia
auricula, Hericium erinaceus, Grifola frondosa
(Maitake), Flammulina velutipes, Pleurotus ostreatus
(Oyster mushroom), Trametes (Coriolus) versicolor,
Tremella fuciformis, Schizophyllum commune and the
nonmushroom Cordyceps sinensis (the caterpillar
fungus). The anti-tumour polysaccharides isolated
from mushrooms include: water-soluble β-D-glucans,
β-D-glucans with heterosaccharide chains of xylose,
mannose, galactose or uronic acid or
β-D-glucan-protein complexes - proteoglycans. Some
are orally bioavailable.
The main medically
important polysaccharide compounds that have
undergone clinical trials include Lentinan (Lentinus
edodes), Schizophyllan (Schizophyllum commune), PSK
and PSP (Trametes versicolor) and Grifron-D (Grifola
frondosa).
Mushroom-derived glucan and polysaccharo-peptides
can act as immunomodulators. The ability of these
compounds to enhance or suppress immune responses
can depend on a number of factors including dosage,
route of administration, timing and frequency of
administration, mechanism of action or the site of
activity. Several mushroom compounds have been shown
to enhance the host’s innate (non-specific) and
acquired (specific) immune responses and activate
many kinds of immune cells that are
important for the maintenance of homeostasis, e.g.
host cells (such as cytotoxic macrophages,
monocytes, neutrophils, natural killer cells,
dendritic cells) and chemical messengers (cytokines
such as interleukins, interferon, colony stimulating
factors) that trigger complement and acute phase
responses.
There have been extensive in vivo studies
demonstrating the anti-cancer activity of the glucan
polysaccharides and polysaccharide-peptides in
animal models. These studies strongly suggest an
immunomodulating mode of action. However, in in
vitro studies on various cancer cell lines, there is
strong evidence for direct cytotoxic effects on the
cancer cells for some, but not all, of the
polysaccharides.
Many of the mushroom polysaccharides have proceeded
through Phase I, II and III clinical trials mainly
in Japan and China. Lentinan (L. edodes) has
demonstrated strong anti-tumor activity in a wide
range of animal models and with human clinical
trials where it has proved successful in prolonging
the survival especially those patients with gastric
and colorectal cancer. Lentinan has been approved as
a drug in Japan and is considered an important
adjuvant treatment for several cancers.
Schizophyllan (S.
commune) has proved useful for recurrent and
inoperable gastric cancer, as well as increasing
survival times of patients with head and neck cancers.
Lingzhi (Ganoderma Lucidum), widely known as Reishi,
is one family of mushrooms that is known for
delivering superior health benefits in China. In
fact, Red Reishi was found to contain some of the
highest concentrations of Polysaccharides and
Triterpenes, both unique in their ability to fight
against certain illnesses. Reishi is also known to
boost the immune system and
enhance overall metabolism and numerous research
papers have been published on its health benefits,
including: anti-tumor, immunotherapeutic, lowering
blood pressure, lowering cholesterol and blood
sugar, improving cardiovascular functions, enhancing
respiratory system and lungs functions, and
chemotherapy support.
In addition, there are several clinical trials with
Grifron-D, GD (G. frondosa) on breast, prostate,
lung, liver and gastric cancers underway in Japan
and U.S. Results to date are promising. In in vitro
studies GD appears to inactivate glyoxalase I, an
enzyme believed to metabolise chemotherapeutic
compounds used against cancer cells thus potentially
enhancing their bioavailability.
Two compounds, PSK and PSP (derived from mycelial
cultures of T. versicolor) have shown worthwhile
anti-cancer properties when given with traditional
chemotherapeutic agents with no increases in
side-effects. PSK has successfully been used in
Phase I, II and III clinical trials with cancers of
the stomach, esophagus, nasopharynx, colon, rectum
and lung, and with subsets of breast cancer. PSK
gave protection against the immunosuppression that
normally is associated with surgery and long-term
chemotherapy. PSK continues to be used extensively
in Japan as an adjunct to standard radio and
chemotherapy.
A significant observation from these studies is the
apparent ability of all of the above
mushroom-derived polysaccharides when administered
with radiotherapy and/or chemotherapy to
significantly reduce the side-effects so often
encountered by patients.
The safety of all medicinal mushrooms or their
extracts cannot be guaranteed simply because they
have been used for many centuries with apparent
safety. However, several purified mushroom
polysaccharides have been in clinical use in Japan,
China and the U.S. for several years with no reports
of any significant short-term or long-term adverse
effects.
Two sources of unique mushroom extracts are Reishi
Essence and Birkdale
Medicinals.
Red Reishi is available from Reishi Essence. This
company’s mission is to deliver the world’s best Red
Reishi extract products at the lowest price.
Therefore, they only carry products with the seal of
approval from the Japan Reishi Association. You can
learn more about Reishi Essence from their website
http://www.reishiessence.com
or call them at
(310)750-5918.
Birkdale Medicinals makes available Immune Assist
24/7 which is a blend of compounds of six medicinal
mushrooms and an extract from green tea called EGCG.
This blend is specifically formulated to stimulate
all the different aspects of the immune system by
increasing the number and activity of the T-cells,
B-cells, natural killer cells and others. You can
learn more about at Birkdale Medicinals from their
website http://www.immuneassist247.com
or call them
at (248) 693-8211.
As required by FDA regulations, these companies make
no claim that their products are a treatment or cure
for any disease.
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Products & Services for Patients and Professionals
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Cancer Medications at Cost
SmartChoiceDrugStore
- SmartChoiceDrugStore (SCD) has
placed its "community first" pricing model into
action by selling cancer medications at cost. SCD's
long-term program covers most cancer medications
including many injectables commonly purchased
through your doctor. Savings can exceed hundreds of
dollars each month. SCD ships nationwide with
typical savings of 10-75%. SmartChoiceDrugStore is a
fully licensed, United States pharmacy. SCD
participates in the Better Business Bureau and
PharmacyChecker verification programs. Patients may
also obtain information about SCD from the Texas
Board of Pharmacy. Medications are only purchased
directly from the manufacturer or the nation's top
wholesale company. Safety is SCD's #1 priority. Call
1-866-289-6337 for more information.
http://www.smartchoicedrugstore.com
Immune Boosting Products
Douglas Laboratories - Douglas Laboratories
has been a manufacturer of quality nutritional
supplements for more than 50 years. It is the
preferred choice of health professionals worldwide.
http://www.douglaslabs.com
Get Healthy Again.com - This company provides
a variety of immune boosting nutritional supplements
designed to enhance the immune system.
http://www.health-reports.com/cancer-conquest.html
Polyerga® Plus - Polyerga® Plus is a unique
nutritional supplement for supporting the immune
system. Although this German-developed spleen
peptide technology has been used in Europe and Asia
for decades, it is only now becoming available in
America. Laboratory and clinically tested to improve
key immune system parameters, these peptides help to
regulate and stabilize the immune system. http://www.polyergaplus.com
Legal Services
Brain Cancer Misdiagnosis Information Center
- Brain Cancer Misdiagnosis Information Center
provides information on the frequency of brain
cancer misdiagnosis, how you can find out if you
have been misdiagnosed, and what you can do about
it. The Center is run by the law firm of Webb,
Scarmozzino & Gunter. http://www.braincancerlaw.com
Cancer Law Center - The Cancer Law Center is
comprised of attorneys with experience in helping
cancer patients whose disease was made worse because
of a delay in diagnosis or whose cancer treatment
led to severe injuries. While many people hesitate
to contact a lawyer, patients should consider their
legal rights if their medical condition was made
worse by medical neglect. http://www.cancerlaw.net
Goldberg, Persky & White, P.C. - This law
firm (and its predecessor law firms) has been a
pioneer in asbestos litigation in the United States.
The attorneys of Goldberg, Persky & White, P.C.
(GPW) have been involved in asbestos and
mesothelioma lawsuits since 1978. Their experienced
mesothelioma lawyers participated in the gathering
of evidence, such as the testimony of corporate
executives and doctors, and the accumulation of
corporate documents, that helped create the basis
for successfully suing the asbestos industry. GPW
has represented thousands of mesothelioma, lung
cancer, and asbestosis victims. Because of their
involvement in asbestos litigation from the
beginning, GPW has a clear understanding of what is
required to succeed. In addition to outstanding
trial experience, GPW is backed by a large arsenal
of corporate documents, depositions, and medical
articles with which to vigorously prosecute your
asbestos case. http://www.gpwlaw.com/cm
Nutritional Support
Haelan Products offers Haelan 951, an
international award-winning, super nutritious,
fermented soybean protein beverage. Clinical
research and numerous reports from doctors and
cancer patients have demonstrated that Haelan 951
helps protect cancer patients from the toxic
side-effects of chemotherapy and radiation
treatments. In addition, one study found that the
soy isoflavone genistein (which is found in Haelan
951) produced greater apoptosis with both
chemotherapy and radiation treatments. Apoptosis
means “programmed cell death” and it is a goal of
most orthodox cancer therapies. Because Haelan 951
is a nutritional supplement, not a cancer treatment,
it was used in this study to offset the toxicity of
the treatments, not as a cancer therapy. http://www.haelan951.com
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