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Non-Hodgkin's Lymphoma treatment details. Chemotherapy, Hormone, Biologic therapy.

Mansoura University, Mansoura, Egypt.

Survival: monthsCountry:Egypt
Toxiciy Grade:5City/State/Province:Mansoura
Treatments:Chemotherapy, Hormone, Biologic therapyHospital:Mansoura University
Drugs:Journal:Link
Date:Nov 2014

Description:

Patients:
This study involved HCV-positive diffuse large B-cell lymphoma patients who were divided into two separate treatment groups. Group A consisted of 200 patients with an average age of 53.6 years; 59.5% were male. Group B had 80 patients with an average age of 53.9 years; 60% were male.

Treatment:
Patients in group A were given chemotherapy (including cyclophosphamide, doxorubicin, and vincristine), the steroid hormone prednisone, and biologic therapy with rituximab.

Patients in group B were given chemotherapy (including cyclophosphamide, doxorubicin, and vincristine), and the steroid hormone prednisone.

Toxicities:
Study-related deaths due to heart failure and liver failure were reported for group A. Grade 4 liver toxicity was also reported.

Study-related deaths due to heart failure and liver failure were reported for group B. Grade 4 liver toxicity was also reported.

Results:
The median overall survival rates for groups A and B were 51 and 43 months, respectively.

Correspondence: Dr. Manal A. Salah-Eldin; email: manasalah@mans.edu.eg



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