Treatment Information

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Breast Cancer treatment details. Chemotherapy, Biologic therapy.

Massachusetts General Hospital Cancer Center, Boston, MA, United States.

Survival: monthsCountry:United States
Toxiciy Grade:4City/State/Province:Boston, MA
Treatments:Chemotherapy, Biologic therapyHospital:Massachusetts General Hospital Cancer Center
Drugs:Journal:Link
Date:Mar 2012

Description:

Patients:
This study involved women with HER2-negative locally advanced or metastatic breast cancer who were divided into two separate treatment groups. Group A had 115 patients with an average age of 55.1 years. Group B consisted of 114 patients with an average age of 54.4 years.

Treatment:
Patients in group A were treated with the biologic therapy agent sorafenib (an inhibitor of kinase proteins which are involved in cancer cell growth) and the chemotherapy agent capecitabine.

Patients in group B were treated with the chemotherapy agent capecitabine only.

Toxicities:
The most severe treatment-related toxicity in group A was grade 4 neutropenia. Grade 3 hand-foot skin reaction, diarrhea, rash, and shortness of breath were also reported.

There were two treatment-related deaths due to unspecified causes in group B. Grade 4 mucosal inflammation, neutropenia, and shortness of breath were also reported.

Results:
The median overall survival for group A was 22.2 months. For group B, the median overall survival was 20.9 months.

Support: This study was partially supported by Onyx Pharmaceuticals and Bayer HealthCare Pharmaceuticals.

Correspondence: Dr. Jose Baselga; email: [email protected]



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