Treatment Information

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Colon Cancer treatment details. Chemotherapy, Biologic therapy.

Oslo University Hospital, Oslo, Norway.

Survival: monthsCountry:Norway
Toxiciy Grade:4City/State/Province:Oslo
Treatments:Chemotherapy, Biologic therapyHospital:Oslo University Hospital
Drugs:Journal:Link
Date:May 2012

Description:

Patients:
This study involved previously untreated metastatic colorectal cancer patients who were divided into separate treatment groups. Group A consisted of 185 patients with a median age of 61.8 years; 54% were male. Group B had 194 patients with a median age of 60.8 years and 62% male.

Treatment:
Patients in group A were treated with the chemotherapy agents fluorouracil, folinic acid, and oxaliplatin.

Patients in group B were treated with the chemotherapy agents fluorouracil, folinic acid, and oxaliplatin, and the biologic therapy agent cetuximab.

Toxicities:
The most severe treatment-related toxicity in group A was of grade 4. Grade 3-4 toxicities included neutropenia, fatigue, and sensory neuropathy (nerve disorders).

The most severe treatment-related toxicity in group B was of grade 4. Grade 3-4 toxicities included neutropenia, diarrhea, and rash.

Results:
The median overall survival for group A and B was 20.4 and 19.7 months, respectively.

Support:
This study was supported by the pharmaceutical companies Merck Serono and Sanofi-Aventis.

Correspondence: Dr. Kjell Magne Tveit; email: [email protected]



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