Treatment Information


Bladder Cancer treatment details. Chemotherapy, Surgery.

Sapporo Medical University School of Medicine, Sapporo, Japan.

Survival: monthsCountry:Japan
Toxiciy Grade:4City/State/Province:Sapporo
Treatments:Chemotherapy, SurgeryHospital:Sapporo Medical University School of Medicine
Date:Jun 2014


This phase 3 study involved muscle-invasive bladder cancer patients who were divided into two separate treatment groups. Group A consisted of 66 patients with a median age of 63 years; 60 were male. Group B had 64 patients with a median age of 63 years; 57 were male.

Patients in group A received surgery (radical cystectomy).

Patients in group B received chemotherapy with methotrexate, doxorubicin, vinblastine and cisplatin, and surgery (radical cystectomy).

The most severe toxicities in group A were of grade 4 and included grade 3-4 infection and thrombosis (blood clot).

The most severe toxicities in group B were grade 4 neutropenia and anemia. Grade 3 loss of appetite and nausea was also reported.

The median overall survival for groups A and B were 82 and 102 months, respectively.

Correspondence: Dr. Hiroshi Kitamura; email: