Treatment Information


Colon Cancer treatment details. Chemotherapy, Biologic therapy.

Cancer Therapy and Research Center, San Antonio TX, United States.

Survival: monthsCountry:United States
Toxiciy Grade:4City/State/Province:San Antonio TX
Treatments:Chemotherapy, Biologic therapyHospital:Cancer Therapy and Research Center
Date:Dec 2005


Patients: This Phase I study involved 20 patients with metastatic colorectal cancer.

Treatment: The treatment consisted of one biologic agent (oblimersen, which is an antisense oligonucleotide directed to the Bcl-2 mRNA) and one chemotherapeutic agent (irinotecan).

Toxicity: Grade 3-4 toxicities included neutropenia, thrombocytopenia, anemia, lymphopenia, and diarrhea.

Results: One patient experienced a partial response and 10 additional patients had stable disease lasting 2.5–10 months. Median survival was not reported.

Correspondence: Dr A. W. Tolcher