Treatment Information


Breast Cancer treatment details. Chemotherapy, Biologic therapy.

Vancouver Cancer Centre, Vancouver, B.C., Canada.

Survival: monthsCountry:Canada
Toxiciy Grade:3City/State/Province:Vancouver, B.C.
Treatments:Chemotherapy, Biologic therapyHospital:Vancouver Cancer Centre
Date:May 2006


Patients: This Phase II trial involved a total of 30 women with HER-2 overexpressing metastatic breast cancer.

Treatment: The treatment consisted of chemotherapy (pegylated liposomal doxorubicin) and biological therapy trastuzumab (herceptin) a type of monoclonal antibody.

Toxicity: Grade 3-4 toxicities included mucositis, hand-foot syndrome, and neutropenia.

Results: The authors report that at a median follow-up of 13.9 months, the median progression-free survival was 12.0 months and the median overall survival has not yet been reached.

Support: One author was an employee of Schering Canada. Another was a consultant with Schering Plough and had received honoraria from Schering Plough and Hoffman la Roche. Three more authors received honoraria from Roche, Hoffman LaRoche and Genetech, and Schering Canada.

Correspondence: Stephen Chia, MD