Treatment Information

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Prostate Cancer treatment details. Radiation, Biologic therapy.

Mayo Clinic, Rochester, MN, United States.

Survival: monthsCountry:United States
Toxiciy Grade:5City/State/Province:Rochester, MN
Treatments:Radiation, Biologic therapyHospital:Mayo Clinic
Drugs:Journal:Link
Date:May 2014

Description:

Patients:
This phase 3 study involved metastatic castration-resistant prostate cancer patients with bone metastases who had received prior treatment with docetaxel. Patients were divided into two treatment groups. Group A consisted of 399 patients with a median age of 69 years. Group B had of 400 patients with a median age of 67.5 years.

Treatment:
Patients in group A were treated with radiation therapy and ipilimumab, a biologic therapy agent.

Patients in group B received radiation therapy and a placebo.

Toxicities:
Treatment-related deaths due to pneumonia and general deterioration of health were reported for group A. Grade 4 diarrhea, fatigue, and colitis were also reported.

Treatment-related deaths due to dehydration and general deterioration of health were reported for group B. Grade 4 fatigue, anemia, and back pain were also reported.

Results:
The median overall survival rates for groups A and B were 11.2 and 10.0 months, respectively.

Support:
This study was supported by Bristol-Myers Squibb.

Correspondence: Dr. Eugene D Kwon; email: [email protected]



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