Treatment Information

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Mesothelioma treatment details. Chemotherapy.

University of Chicago Medical Center, Chicago, Illinois, United States.

Survival: monthsCountry:United States
Toxiciy Grade:5City/State/Province:Chicago, Illinois
Treatments:ChemotherapyHospital:University of Chicago Medical Center
Drugs:Journal:Link
Date:Nov 1999

Description:

Patients: This Phase II study involved 20 patients with malignant mesothelioma who could not be treated by surgery or radiation alone.

Treatment: The treatment consisted of administration of the drug edatrexate.

Toxicity: Four patients died without documentation of progressive disease. These deaths involved neutropenic sepsis, cardiac arrest, and respiratory failure from progressive mesothelioma. Grade 3-4 toxicities included hematologic, infection, nausea, emesis, muscositis, esophagitis/dysphagia, dermatologic, anorexia, malaise/fatigue, cardiac, pulmonary, renal, hepatic, and neurologic.

Results: The median survival duration was 9.6 months.




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