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Mesothelioma treatment details. Chemotherapy, Biologic therapy.

Institut Jules Bordet, Brussels, Belgium.

Survival: monthsCountry:Belgium
Toxiciy Grade:5City/State/Province:Brussels
Treatments:Chemotherapy, Biologic therapyHospital:Institut Jules Bordet
Drugs:Journal:Link
Date:Jan 2011

Description:

Patients:
This phase 2 study involved 45 malignant mesothelioma patients who had received prior platinum-based therapy. The median age was 69 years (range of 51-80) and 73% were male.

Treatment:
Patients were treated with the biologic therapy valproic acid, a histone deacetylase inhibitor, and the chemotherapy agent doxorubicin.

Toxicities:
Treatment-related deaths due to febrile neutropenia and cerebral thromboembolism (stroke) were reported. Grade 4 leucopenia and neutropenia and grade 3 alopecia were also reported.

Results:
The median progression-free survival was 2.5 months and the median overall survival was 6.7 months.

Correspondence: Dr. T. Berghmans; email: [email protected]



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