Treatment Information

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Non-Hodgkin's Lymphoma treatment details. Chemotherapy, Biologic therapy.

The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States.

Survival: monthsCountry:United States
Toxiciy Grade:4City/State/Province:Houston, Texas
Treatments:Chemotherapy, Biologic therapyHospital:The University of Texas M. D. Anderson Cancer Center
Drugs:Journal:Link
Date:Nov 2008

Description:

Patients:
This phase 2 study involved 31 relapsed or refractory aggressive mantle cell lymphoma patients. The median patient age was 63 years and the male to female ratio was 5 to 1.

Treatment:
Patients were treated with the biologic therapy agent rituximab, the chemotherapy combination called CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone), and the chemotherapy drug methotrexate-cytarabine.

Toxicities:
The most severe toxicities were grade 4 neutropenia and thrombocytopenia. Grade 2 swelling, vomiting, and constipation were also reported.

Results:
The median overall survival was 19 months.

Support:
Some of the authors have received funding from various pharmaceutical companies.

Correspondence: Dr. Jorge E. Romaguera; email: [email protected]



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