Treatment Information

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Brain – Glioblastoma Multiforme treatment details. Chemotherapy, Radiation.

Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.

Survival: monthsCountry:Italy
Toxiciy Grade:4City/State/Province:Milan
Treatments:Chemotherapy, RadiationHospital:Istituto Nazionale Neurologico Carlo Besta
Drugs:Journal:Link
Date:Dec 2002

Description:

Patients: This study involved 30 newly diagnosed patients with glioblastoma multiforme. The patients were divided into two groups (A and B) of 15 patients each.

Treatment: Patients in Group A received intraarterial chemotherapy consisting of carboplatin (paraplatin) plus ACNU. Patients in Group B received intravenous chemotherapy consisting of cisplatin plus BCNU. After the second course of chemotherapy and before the third cycle, all patients received radiotherapy.

Toxicity: For group A, grade 3 and 4 leukopenia occurred in 3 patients and 1 patient respectively. Grade 3 thrombocytopenia occurred in 1 patient. One patient experienced focal seizures several hours after the end of treatment. One patient developed an intraparenchymal hematoma involving the right middle cerebral artery.

Results: Median survival time was 18.3 months (group A).




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