Treatment Information

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Melanoma treatment details. Chemotherapy, Biologic therapy.

St. Mary's Medical Center, San Francisco, CA, United States.

Survival: monthsCountry:United States
Toxiciy Grade:4City/State/Province:San Francisco, CA
Treatments:Chemotherapy, Biologic therapyHospital:St. Mary's Medical Center
Drugs:Journal:Link
Date:Feb 2015

Description:

Patients:
This phase 2 study involved 50 metastatic melanoma patients who had not received prior chemotherapy. The median patient age was 62 years and 64% were male.

Treatment:
Patients received chemotherapy with nab-paclitaxel and biologic therapy with bevacizumab.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 neutropenia and peripheral neuropathy (nerve toxicity). Bowel perforation, hand-foot skin reaction, and macular edema (swelling of the eye) were also reported.
Results:
The median overall survival was 16.8 months.

Support:
This study was partially supported by Celgene Corporation and Genentech/Roche.

Correspondence: Dr. Lynn E. Spitler; email: [email protected]



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