Treatment Information

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Ovarian Cancer treatment details. Chemotherapy, Biologic therapy.

Departments of Medical Oncology, Mayo, Rochester, MN, United States.

Survival: monthsCountry:United States
Toxiciy Grade:5City/State/Province:Rochester, MN
Treatments:Chemotherapy, Biologic therapyHospital:Departments of Medical Oncology, Mayo
Drugs:Journal:Link
Date:Apr 2011

Description:

Patients:
This study involved 18 women with platinum refractory or resistant ovarian or peritoneal cancer. The median patient age was 66 years. All patients had previously been treated with platinum-based therapy.

Treatment:
Patients in this study were treated with the chemotherapy agent topotecan and the biologic therapy lapatinib, which is a tyrosine kinase inhibitor.

Toxicities:
There was one death reported as a grade 5 adverse event, however, the reported cause was disease progression not due to treatment. Otherwise, grade 4 neutropenia (3 patients) and diarrhea (1), as well as grade 3 dehydration (2) was reported.

Results:
The reported median overall survival was 15.5 months.

Support:
This study was supported by GlaxoSmithKline, the makers of lapatinib (brand name Tykerb) and topotecan (brand name Hycamtin).

Correspondence: Dr. Paul Haluska; email: [email protected]



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