Treatment Information

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Breast Cancer treatment details. Chemotherapy, Biologic therapy.

Memorial Sloan-Kettering Cancer Center, New York, NY, United States.

Survival: monthsCountry:United States
Toxiciy Grade:5City/State/Province:New York, NY
Treatments:Chemotherapy, Biologic therapyHospital:Memorial Sloan-Kettering Cancer Center
Drugs:Journal:Link
Date:Jan 2014

Description:

Patients:
This phase 3 study involved female HER2-positive metastatic breast cancer patients who were divided into two separate treatment groups. Group A consisted of 181 patients and group B had 182 patients. No patient age information was available.

Treatment:
Patients in group A received chemotherapy with nonpegylated liposomal doxorubicin and paclitaxel in addition to biologic therapy with trastuzumab.

Patients in group B received chemotherapy with paclitaxel and biologic therapy with trastuzumab.

Toxicities:
Treatment-related deaths due to unspecified causes were reported for group A. Grade 3-4 neutropenia, leucopenia, and stomatitis (inflammation of the lining of the GI tract) were also reported.

Treatment-related deaths due to unspecified causes were reported for group B. Grade 3-4 neutropenia and nerve toxicity were also reported.

Results:
The median overall survival times for groups A and B were 33.6 and 28.9 months, respectively.

Support:
This study was supported by Sopherion Therapeutics, makers of nonpegylated liposomal doxorubicin (brand name: Myocet).

Correspondence: Dr. José Baselga; email: baselgaj@mskcc.org



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