Hyped by biotech, Wall Street and the media, gene therapy became another cancer buzz word in the 1990’s. This new space-age modality was supposed to garner breakthroughs in the treatment of various debilitating and deadly disease especially cancer. Today, there is no FDA approved gene therapy for cancer or any other disease. What happened? In this article we will take a look at the failed promise of gene therapy and focus on a related modality of greater potential – epigene therapy.